Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells

Activation-induced cytidine deaminase (AID) is required for initiation of Ig class switch recombination (CSR) and somatic hypermutation (SHM) of antibody genes during immune responses. AID has also been shown to induce chromosomal translocations, mutations, and DNA double-strand breaks (DSBs) involv...

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Detalles Bibliográficos
Autores principales: Khair, Lyne, Baker, Richard E., Linehan, Erin K., Schrader, Carol E., Stavnezer, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532491/
https://www.ncbi.nlm.nih.gov/pubmed/26263206
http://dx.doi.org/10.1371/journal.pgen.1005438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532491/
https://www.ncbi.nlm.nih.gov/pubmed/26263206
http://dx.doi.org/10.1371/journal.pgen.1005438

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