The Fcp1-Wee1-Cdk1 axis affects spindle assembly checkpoint robustness and sensitivity to antimicrotubule cancer drugs

To grant faithful chromosome segregation, the spindle assembly checkpoint (SAC) delays mitosis exit until mitotic spindle assembly. An exceedingly prolonged mitosis, however, promotes cell death and by this means antimicrotubule cancer drugs (AMCDs), that impair spindle assembly, are believed to kil...

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Detalles Bibliográficos
Autores principales: Visconti, R, Della Monica, R, Palazzo, L, D'Alessio, F, Raia, M, Improta, S, Villa, M R, Del Vecchio, L, Grieco, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532778/
https://www.ncbi.nlm.nih.gov/pubmed/25744022
http://dx.doi.org/10.1038/cdd.2015.13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532778/
https://www.ncbi.nlm.nih.gov/pubmed/25744022
http://dx.doi.org/10.1038/cdd.2015.13

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