Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition

Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) mutations in PDAC cohorts. Here we report that conditional deletion of ATM in a mouse model of PDAC indu...

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Detalles Bibliográficos
Autores principales: Russell, Ronan, Perkhofer, Lukas, Liebau, Stefan, Lin, Qiong, Lechel, André, Feld, Fenja M, Hessmann, Elisabeth, Gaedcke, Jochen, Güthle, Melanie, Zenke, Martin, Hartmann, Daniel, von Figura, Guido, Weissinger, Stephanie E, Rudolph, Karl-Lenhard, Möller, Peter, Lennerz, Jochen K, Seufferlein, Thomas, Wagner, Martin, Kleger, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532798/
https://www.ncbi.nlm.nih.gov/pubmed/26220524
http://dx.doi.org/10.1038/ncomms8677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532798/
https://www.ncbi.nlm.nih.gov/pubmed/26220524
http://dx.doi.org/10.1038/ncomms8677

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