Co-Stimulatory Blockade of the CD28/CD80-86/CTLA-4 Balance in Transplantation: Impact on Memory T Cells?

CD28 and CTLA-4 are prototypal co-stimulatory and co-inhibitory cell surface signaling molecules interacting with CD80/86, known to be critical for immune response initiation and regulation, respectively. Initial “bench-to-beside” translation, two decades ago, resulted in the development of CTLA4-Ig...

Descripción completa

Detalles Bibliográficos
Autores principales: Ville, Simon, Poirier, Nicolas, Blancho, Gilles, Vanhove, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532816/
https://www.ncbi.nlm.nih.gov/pubmed/26322044
http://dx.doi.org/10.3389/fimmu.2015.00411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532816/
https://www.ncbi.nlm.nih.gov/pubmed/26322044
http://dx.doi.org/10.3389/fimmu.2015.00411

Ejemplares similares