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The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins

Understanding the directionality and sequence of protein unfolding is crucial to elucidate the underlying folding free energy landscape. An extra layer of complexity is added in metalloproteins, where a metal cofactor participates in the correct, functional fold of the protein. However, the precise...

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Detalles Bibliográficos
Autores principales: Beedle, Amy E. M., Lezamiz, Ainhoa, Stirnemann, Guillaume, Garcia-Manyes, Sergi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532836/
https://www.ncbi.nlm.nih.gov/pubmed/26235284
http://dx.doi.org/10.1038/ncomms8894