An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer

High-grade serous ovarian cancers (HGSCs) are deadly malignancies that relapse despite carboplatin chemotherapy. Here we show that 16 independent primary HGSC samples contain a CA125-negative population enriched for carboplatin-resistant cancer initiating cells. Transcriptome analysis reveals upregu...

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Detalles Bibliográficos
Autores principales: Janzen, D. M., Tiourin, E., Salehi, J. A., Paik, D. Y., Lu, J., Pellegrini, M., Memarzadeh, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532886/
https://www.ncbi.nlm.nih.gov/pubmed/26234182
http://dx.doi.org/10.1038/ncomms8956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532886/
https://www.ncbi.nlm.nih.gov/pubmed/26234182
http://dx.doi.org/10.1038/ncomms8956

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