Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro

In-vitro expansion of functional adult human β-cells is an attractive approach for generating insulin-producing cells for transplantation. However, human islet cell expansion in culture results in loss of β-cell phenotype and epithelial-mesenchymal transition (EMT). This process activates expression...

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Detalles Bibliográficos
Autores principales: Sintov, Elad, Nathan, Gili, Knoller, Sarah, Pasmanik-Chor, Metsada, Russ, Holger A., Efrat, Shimon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532995/
https://www.ncbi.nlm.nih.gov/pubmed/26264186
http://dx.doi.org/10.1038/srep13024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532995/
https://www.ncbi.nlm.nih.gov/pubmed/26264186
http://dx.doi.org/10.1038/srep13024

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