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TRPA1 mediates the hypothermic action of acetaminophen

Acetaminophen (APAP) is an effective antipyretic and one of the most commonly used analgesic drugs. Unlike antipyretic non-steroidal anti-inflammatory drugs, APAP elicits hypothermia in addition to its antipyretic effect. Here we have examined the mechanisms responsible for the hypothermic activity...

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Detalles Bibliográficos
Autores principales: Gentry, Clive, Andersson, David A., Bevan, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533162/
https://www.ncbi.nlm.nih.gov/pubmed/26227887
http://dx.doi.org/10.1038/srep12771