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Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction

CD6 is a transmembrane protein with an extracellular region containing three scavenger receptor cysteine rich (SRCR) domains. The membrane proximal domain of CD6 binds the N-terminal immunoglobulin superfamily (IgSF) domain of another cell surface receptor, CD166, which also engages in homophilic in...

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Detalles Bibliográficos
Autores principales: Chappell, Paul E., Garner, Lee I., Yan, Jun, Metcalfe, Clive, Hatherley, Deborah, Johnson, Steven, Robinson, Carol V., Lea, Susan M., Brown, Marion H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533223/
https://www.ncbi.nlm.nih.gov/pubmed/26146185
http://dx.doi.org/10.1016/j.str.2015.05.019