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Two single amino acid substitutions in the intervening region of Newcastle disease virus HN protein attenuate viral replication and pathogenicity

Among the proteins encoded by Newcastle disease virus (NDV), the attachment protein (HN) is an important determinant of virulence and pathogenicity. HN has been molecularly characterized at the protein level; however, the relationship between the molecular character of HN and the animal pathotype it...

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Detalles Bibliográficos
Autores principales: Liu, Bin, Ji, Yanhong, Lin, Zhongqing, Fu, Yuguang, Muhammad Dafallah, Rihab, Zhu, Qiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533526/
https://www.ncbi.nlm.nih.gov/pubmed/26267791
http://dx.doi.org/10.1038/srep13038