Cargando…

Conditionally replicating adenovirus prevents pluripotent stem cell–derived teratoma by specifically eliminating undifferentiated cells

Incomplete abolition of tumorigenicity creates potential safety concerns in clinical trials of regenerative medicine based on human pluripotent stem cells (hPSCs). Here, we demonstrate that conditionally replicating adenoviruses that specifically target cancers using multiple factors (m-CRAs), origi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mitsui, Kaoru, Ide, Kanako, Takayama, Akiko, Wada, Tadahisa, Irie, Rie, Kosai, Ken-ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533615/ https://www.ncbi.nlm.nih.gov/pubmed/26269798 http://dx.doi.org/10.1038/mtm.2015.26

Ejemplares similares

Viral Vector-Based Innovative Approaches to Directly Abolishing Tumorigenic Pluripotent Stem Cells for Safer Regenerative Medicine
por: Mitsui, Kaoru, et al.
Publicado: (2017)

Survivin-responsive conditionally replicating adenovirus kills rhabdomyosarcoma stem cells more efficiently than their progeny
por: Tanoue, Kiyonori, et al.
Publicado: (2014)

MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells
por: Parr, Callum J. C., et al.
Publicado: (2016)

Plasma-activated medium selectively eliminates undifferentiated human induced pluripotent stem cells
por: Matsumoto, Ryo, et al.
Publicado: (2016)

Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy
por: Watanabe, Maki, et al.
Publicado: (2021)

The MicroRNA-371 Family as Plasma Biomarkers for Monitoring Undifferentiated and Potentially Malignant Human Pluripotent Stem Cells in Teratoma Assays
por: Salvatori, Daniela C.F., et al.
Publicado: (2018)

Salicylic diamines selectively eliminate residual undifferentiated cells from pluripotent stem cell-derived cardiomyocyte preparations
por: Burkert, Karsten, et al.
Publicado: (2021)

Reversible transformation and de-differentiation of human cells derived from induced pluripotent stem cell teratomas
por: Kamada, Mizuna, et al.
Publicado: (2015)

Cisplatin induces differentiation in teratomas derived from pluripotent stem cells
por: Kurata, Atsushi, et al.
Publicado: (2021)

Prostatic relapse of an undifferentiated teratoma 24 years after orchidectomy
por: Janowitz, Tobias, et al.
Publicado: (2015)

Murine pluripotent stem cells that escape differentiation inside teratomas maintain pluripotency
por: Pei, Yangli, et al.
Publicado: (2018)

Elimination of undifferentiated human embryonic stem cells by cardiac glycosides
por: Lin, Yu-Tsen, et al.
Publicado: (2017)

UNDIFFERENTIATED SARCOMA ARISING IN AN IMMATURE TERATOMA OF THE OVARY: A case report
por: Mekni, K., et al.
Publicado: (2022)

A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma
por: Suzuki, Shinsuke, et al.
Publicado: (2019)

Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells
por: Yanagihara, Kana, et al.
Publicado: (2016)

Malignant transformation of mature cystic teratoma into undifferentiated carcinoma: A case report
por: Aryal, Vinayak, et al.
Publicado: (2021)

Preventing Pluripotent Cell Teratoma in Regenerative Medicine Applied to Hematology Disorders
por: Bedel, Aurelie, et al.
Publicado: (2016)

Expression of Chrna9 is regulated by Tbx3 in undifferentiated pluripotent stem cells
por: Yazawa, Takashi, et al.
Publicado: (2023)

A Rare Urothelial Malignant Transformation in a Mature Cystic Teratoma of the Ovary
por: Iijima, Moito, et al.
Publicado: (2021)

Attenuation of teratoma formation by p27 overexpression in induced pluripotent stem cells
por: Matsu-ura, Toru, et al.
Publicado: (2016)

Defining the Skeletal Myogenic Lineage in Human Pluripotent Stem Cell-Derived Teratomas
por: Pappas, Matthew P., et al.
Publicado: (2022)

Sialyl-lactotetra, a Novel Cell Surface Marker of Undifferentiated Human Pluripotent Stem Cells
por: Barone, Angela, et al.
Publicado: (2014)

Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies
por: Chour, Tony, et al.
Publicado: (2021)

Intramyocardial Transplantation of Undifferentiated Rat Induced Pluripotent Stem Cells Causes Tumorigenesis in the Heart
por: Zhang, Yuzhen, et al.
Publicado: (2011)

Immunoreactivity of Pluripotent Markers SSEA-5 and L1CAM in Human Tumors, Teratomas, and Induced Pluripotent Stem Cells
por: Cassidy, Linda, et al.
Publicado: (2013)

Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays
por: Bouma, Marga J., et al.
Publicado: (2017)

Standardization of the Teratoma Assay for Analysis of Pluripotency of Human ES Cells and Biosafety of Their Differentiated Progeny
por: Gropp, Michal, et al.
Publicado: (2012)

The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse
por: Zheng, Ke, et al.
Publicado: (2009)

Natural Killer Cells Prevent the Formation of Teratomas Derived From Human Induced Pluripotent Stem Cells
por: Benabdallah, Basma, et al.
Publicado: (2019)

Spindle and Giant Cell Type Undifferentiated Carcinoma of the Proximal Bile Duct
por: Ide, Takao, et al.
Publicado: (2012)

Imaging-cytometry revealed spatial heterogeneities of marker expression in undifferentiated human pluripotent stem cells
por: Suga, Mika, et al.
Publicado: (2016)

Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease
por: Muñoz, Antonio, et al.
Publicado: (2022)

In vivo reprogrammed pluripotent stem cells from teratomas share analogous properties with their in vitro counterparts
por: Choi, Hyun Woo, et al.
Publicado: (2015)

Spontaneous Regression of Recurrent Undifferentiated Carcinoma of the Endometrium
por: Ishii, Tadashi, et al.
Publicado: (2019)

Repair of Ischemic Injury by Pluripotent Stem Cell Based Cell Therapy without Teratoma through Selective Photosensitivity
por: Cho, Seung-Ju, et al.
Publicado: (2015)

A selective cytotoxic adenovirus vector for concentration of pluripotent stem cells in human pluripotent stem cell-derived neural progenitor cells
por: Hirai, Takamasa, et al.
Publicado: (2021)

Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells
por: Nesterova, Tatyana B, et al.
Publicado: (2011)

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition
por: Miyazaki, Yumi, et al.
Publicado: (2016)

Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors
por: Chakraborty, Arup R., et al.
Publicado: (2022)

Heparin-binding epidermal growth factor-like growth factor and hepatocyte growth factor inhibit cholestatic liver injury in mice through different mechanisms
por: Sakamoto, Kouichi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_cpfulvnqo8j903m2non4kb6dse