Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition

Proteoglycan degradation contributing to the pathogenesis of intervertebral disc (IVD) degeneration is induced by inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Cell autophagy exists in degenerative diseases, including osteoarthritis and inter-vertebral d...

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Detalles Bibliográficos
Autores principales: XU, KANG, CHEN, WEIJIAN, WANG, XIAOFEI, PENG, YAN, LIANG, ANJING, HUANG, DONGSHENG, LI, CHUNHAI, YE, WEI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533778/
https://www.ncbi.nlm.nih.gov/pubmed/26165348
http://dx.doi.org/10.3892/ijmm.2015.2280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533778/
https://www.ncbi.nlm.nih.gov/pubmed/26165348
http://dx.doi.org/10.3892/ijmm.2015.2280

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