Individual Substitution Mutations in the AID C Terminus That Ablate IgH Class Switch Recombination

Activation-induced cytidine deaminase (AID) is essential for class switch recombination (CSR) and somatic hypermutation (SHM) of Ig genes. The C terminus of AID is required for CSR but not for SHM, but the reason for this is not entirely clear. By retroviral transduction of mutant AID proteins into...

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Detalles Bibliográficos
Autores principales: Kadungure, Tatenda, Ucher, Anna J., Linehan, Erin K., Schrader, Carol E., Stavnezer, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534307/
https://www.ncbi.nlm.nih.gov/pubmed/26267846
http://dx.doi.org/10.1371/journal.pone.0134397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534307/
https://www.ncbi.nlm.nih.gov/pubmed/26267846
http://dx.doi.org/10.1371/journal.pone.0134397

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