One Size Doesn't Fit All - RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping and Genotype Calling in Next Generation Sequencing Studies

With rapid decline of the sequencing cost, researchers today rush to embrace whole genome sequencing (WGS), or whole exome sequencing (WES) approach as the next powerful tool for relating genetic variants to human diseases and phenotypes. A fundamental step in analyzing WGS and WES data is mapping s...

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Detalles Bibliográficos
Autores principales: Yuan, Shuai, Johnston, H. Richard, Zhang, Guosheng, Li, Yun, Hu, Yi-Juan, Qin, Zhaohui S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534450/
https://www.ncbi.nlm.nih.gov/pubmed/26267278
http://dx.doi.org/10.1371/journal.pcbi.1004448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534450/
https://www.ncbi.nlm.nih.gov/pubmed/26267278
http://dx.doi.org/10.1371/journal.pcbi.1004448

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