Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin

Shiga toxin (Stx) causes fatal systemic complications. Stx induces apoptosis, but the mechanism of which is unclear. We report that Stx induced rapid reduction of short-lived anti-apoptotic proteins followed by activation of caspase 9 and the progression of apoptosis. Proteasome inhibitors prevented...

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Detalles Bibliográficos
Autores principales: Hattori, Takayuki, Watanabe-Takahashi, Miho, Ohoka, Nobumichi, Hamabata, Takashi, Furukawa, Koichi, Nishikawa, Kiyotaka, Naito, Mikihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534485/
https://www.ncbi.nlm.nih.gov/pubmed/26273560
http://dx.doi.org/10.1016/j.fob.2015.06.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534485/
https://www.ncbi.nlm.nih.gov/pubmed/26273560
http://dx.doi.org/10.1016/j.fob.2015.06.005

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