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Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming
Hypothermia is potently neuroprotective but poor mechanistic understanding has restricted its clinical use. Rodent studies indicate that hypothermia can elicit preconditioning, wherein a subtoxic cellular stress confers resistance to an otherwise lethal injury. The molecular basis of this preconditi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534756/ https://www.ncbi.nlm.nih.gov/pubmed/26287272 http://dx.doi.org/10.1016/j.ebiom.2015.04.004 |