A critical role of toll-like receptor 2 (TLR2) and its’ in vivo ligands in radio-resistance

The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2(−/−)) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2(−/−) mice. The cause of death in TLR2(−/−) m...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Fu, Zhang, Chaoxiong, Zhou, Chuanfeng, Sun, Weimin, Liu, Xin, Zhang, Pei, Han, Jiaqi, Xian, Linfeng, Bai, Dongchen, Liu, Hu, Cheng, Ying, Li, Bailong, Cui, Jianguo, Cai, Jianming, Liu, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534783/
https://www.ncbi.nlm.nih.gov/pubmed/26268450
http://dx.doi.org/10.1038/srep13004
_version_ 1782385509463490560
author Gao, Fu
Zhang, Chaoxiong
Zhou, Chuanfeng
Sun, Weimin
Liu, Xin
Zhang, Pei
Han, Jiaqi
Xian, Linfeng
Bai, Dongchen
Liu, Hu
Cheng, Ying
Li, Bailong
Cui, Jianguo
Cai, Jianming
Liu, Cong
author_facet Gao, Fu
Zhang, Chaoxiong
Zhou, Chuanfeng
Sun, Weimin
Liu, Xin
Zhang, Pei
Han, Jiaqi
Xian, Linfeng
Bai, Dongchen
Liu, Hu
Cheng, Ying
Li, Bailong
Cui, Jianguo
Cai, Jianming
Liu, Cong
author_sort Gao, Fu
collection PubMed
description The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2(−/−)) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2(−/−) mice. The cause of death in TLR2(−/−) mice may be severe and persistent bone marrow cell loss. Injection of the TLR2 agonist Pam(3)CSK(4) into wild type (WT) mice induced radio-resistance. Myd88(−/−) mice were more susceptible to radiation. In conclusion, our data indicate that, similar to TLR4, TLR2 plays a critical role in radio-resistance.
format Online
Article
Text
id pubmed-4534783
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-45347832015-08-21 A critical role of toll-like receptor 2 (TLR2) and its’ in vivo ligands in radio-resistance Gao, Fu Zhang, Chaoxiong Zhou, Chuanfeng Sun, Weimin Liu, Xin Zhang, Pei Han, Jiaqi Xian, Linfeng Bai, Dongchen Liu, Hu Cheng, Ying Li, Bailong Cui, Jianguo Cai, Jianming Liu, Cong Sci Rep Article The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2(−/−)) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2(−/−) mice. The cause of death in TLR2(−/−) mice may be severe and persistent bone marrow cell loss. Injection of the TLR2 agonist Pam(3)CSK(4) into wild type (WT) mice induced radio-resistance. Myd88(−/−) mice were more susceptible to radiation. In conclusion, our data indicate that, similar to TLR4, TLR2 plays a critical role in radio-resistance. Nature Publishing Group 2015-08-13 /pmc/articles/PMC4534783/ /pubmed/26268450 http://dx.doi.org/10.1038/srep13004 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Gao, Fu
Zhang, Chaoxiong
Zhou, Chuanfeng
Sun, Weimin
Liu, Xin
Zhang, Pei
Han, Jiaqi
Xian, Linfeng
Bai, Dongchen
Liu, Hu
Cheng, Ying
Li, Bailong
Cui, Jianguo
Cai, Jianming
Liu, Cong
A critical role of toll-like receptor 2 (TLR2) and its’ in vivo ligands in radio-resistance
title A critical role of toll-like receptor 2 (TLR2) and its’ in vivo ligands in radio-resistance
title_full A critical role of toll-like receptor 2 (TLR2) and its’ in vivo ligands in radio-resistance
title_fullStr A critical role of toll-like receptor 2 (TLR2) and its’ in vivo ligands in radio-resistance
title_full_unstemmed A critical role of toll-like receptor 2 (TLR2) and its’ in vivo ligands in radio-resistance
title_short A critical role of toll-like receptor 2 (TLR2) and its’ in vivo ligands in radio-resistance
title_sort critical role of toll-like receptor 2 (tlr2) and its’ in vivo ligands in radio-resistance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534783/
https://www.ncbi.nlm.nih.gov/pubmed/26268450
http://dx.doi.org/10.1038/srep13004
work_keys_str_mv AT gaofu acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT zhangchaoxiong acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT zhouchuanfeng acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT sunweimin acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT liuxin acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT zhangpei acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT hanjiaqi acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT xianlinfeng acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT baidongchen acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT liuhu acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT chengying acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT libailong acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT cuijianguo acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT caijianming acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT liucong acriticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT gaofu criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT zhangchaoxiong criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT zhouchuanfeng criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT sunweimin criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT liuxin criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT zhangpei criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT hanjiaqi criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT xianlinfeng criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT baidongchen criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT liuhu criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT chengying criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT libailong criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT cuijianguo criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT caijianming criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance
AT liucong criticalroleoftolllikereceptor2tlr2anditsinvivoligandsinradioresistance

Ejemplares similares