First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass

Whole-organism chemical screening can circumvent bottlenecks that impede drug discovery. However, in vivo screens have not attained throughput capacities possible with in vitro assays. We therefore developed a method enabling in vivo high-throughput screening (HTS) in zebrafish, termed automated rep...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Guangliang, Rajpurohit, Surendra K, Delaspre, Fabien, Walker, Steven L, White, David T, Ceasrine, Alexis, Kuruvilla, Rejji, Li, Ruo-jing, Shim, Joong S, Liu, Jun O, Parsons, Michael J, Mumm, Jeff S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534842/
https://www.ncbi.nlm.nih.gov/pubmed/26218223
http://dx.doi.org/10.7554/eLife.08261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534842/
https://www.ncbi.nlm.nih.gov/pubmed/26218223
http://dx.doi.org/10.7554/eLife.08261

Ejemplares similares