PARP inhibitors in the management of breast cancer: current data and future prospects

Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. Inhibition of PARPs is a promising strategy for targeting cancers with defective DNA-damage repair, including BRCA1 and BRCA2 mutation-associated breast and ovarian cancers. Several PARP inhibitors are currently in trials...

Descripción completa

Detalles Bibliográficos
Autores principales: Livraghi, Luca, Garber, Judy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535298/
https://www.ncbi.nlm.nih.gov/pubmed/26268938
http://dx.doi.org/10.1186/s12916-015-0425-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535298/
https://www.ncbi.nlm.nih.gov/pubmed/26268938
http://dx.doi.org/10.1186/s12916-015-0425-1

Ejemplares similares