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Statistical inference for extended or shortened phase II studies based on Simon’s two-stage designs
BACKGROUND: Simon’s two-stage designs are popular choices for conducting phase II clinical trials, especially in the oncology trials to reduce the number of patients placed on ineffective experimental therapies. Recently Koyama and Chen (2008) discussed how to conduct proper inference for such studi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535394/ https://www.ncbi.nlm.nih.gov/pubmed/26048655 http://dx.doi.org/10.1186/s12874-015-0039-5 |