Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis

The human pathogen Mycobacterium tuberculosis (Mtb) likely utilizes host fatty acids as a carbon source during infection. Gluconeogenesis is essential for the conversion of fatty acids into biomass. A rate-limiting step in gluconeogenesis is the conversion of fructose 1,6-bisphosphate to fructose 6-...

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Detalles Bibliográficos
Autores principales: Ganapathy, Uday, Marrero, Joeli, Calhoun, Susannah, Eoh, Hyungjin, de Carvalho, Luiz Pedro Sorio, Rhee, Kyu, Ehrt, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535450/
https://www.ncbi.nlm.nih.gov/pubmed/26258286
http://dx.doi.org/10.1038/ncomms8912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535450/
https://www.ncbi.nlm.nih.gov/pubmed/26258286
http://dx.doi.org/10.1038/ncomms8912

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