Cargando…
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis
The human pathogen Mycobacterium tuberculosis (Mtb) likely utilizes host fatty acids as a carbon source during infection. Gluconeogenesis is essential for the conversion of fatty acids into biomass. A rate-limiting step in gluconeogenesis is the conversion of fructose 1,6-bisphosphate to fructose 6-...
Autores principales: | Ganapathy, Uday, Marrero, Joeli, Calhoun, Susannah, Eoh, Hyungjin, de Carvalho, Luiz Pedro Sorio, Rhee, Kyu, Ehrt, Sabine |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535450/ https://www.ncbi.nlm.nih.gov/pubmed/26258286 http://dx.doi.org/10.1038/ncomms8912 |
Ejemplares similares
-
Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis
por: Puckett, Susan, et al.
Publicado: (2014) -
Glucose Phosphorylation Is Required for Mycobacterium tuberculosis Persistence in Mice
por: Marrero, Joeli, et al.
Publicado: (2013) -
Triosephosphate Isomerase Is Dispensable In Vitro yet Essential for Mycobacterium tuberculosis To Establish Infection
por: Trujillo, Carolina, et al.
Publicado: (2014) -
Fructose 1,6-bisphosphatase: getting the message across
por: Timson, David J.
Publicado: (2019) -
Validation of CoaBC as a Bactericidal Target in the
Coenzyme A Pathway of Mycobacterium tuberculosis
por: Evans, Joanna C., et al.
Publicado: (2016)