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The role of protein kinase-C theta in control of epithelial to mesenchymal transition and cancer stem cell formation

The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) induces transition of the epithelial MCF-7 cell line to a mesenchymal phenotype. A subset of the resulting mesenchymal cells has surface markers characteristics of a cancer stem cell (CSC) population. We profiled the transcri...

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Detalles Bibliográficos
Autores principales: Zafar, Anjum, Hardy, Kristine, Wu, Fan, Li, Jasmine, Rao, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535743/
https://www.ncbi.nlm.nih.gov/pubmed/26484144
http://dx.doi.org/10.1016/j.gdata.2014.11.002