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The role of protein kinase-C theta in control of epithelial to mesenchymal transition and cancer stem cell formation
The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) induces transition of the epithelial MCF-7 cell line to a mesenchymal phenotype. A subset of the resulting mesenchymal cells has surface markers characteristics of a cancer stem cell (CSC) population. We profiled the transcri...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535743/ https://www.ncbi.nlm.nih.gov/pubmed/26484144 http://dx.doi.org/10.1016/j.gdata.2014.11.002 |