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The Carboxy Terminus of the Ligand Peptide Determines the Stability of the MHC Class I Molecule H-2K(b): A Combined Molecular Dynamics and Experimental Study
Major histocompatibility complex (MHC) class I molecules (proteins) bind peptides of eight to ten amino acids to present them at the cell surface to cytotoxic T cells. The class I binding groove binds the peptide via hydrogen bonds with the peptide termini and via diverse interactions with the ancho...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535769/ https://www.ncbi.nlm.nih.gov/pubmed/26270965 http://dx.doi.org/10.1371/journal.pone.0135421 |