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The Carboxy Terminus of the Ligand Peptide Determines the Stability of the MHC Class I Molecule H-2K(b): A Combined Molecular Dynamics and Experimental Study

Major histocompatibility complex (MHC) class I molecules (proteins) bind peptides of eight to ten amino acids to present them at the cell surface to cytotoxic T cells. The class I binding groove binds the peptide via hydrogen bonds with the peptide termini and via diverse interactions with the ancho...

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Detalles Bibliográficos
Autores principales:	Abualrous, Esam Tolba, Saini, Sunil Kumar, Ramnarayan, Venkat Raman, Ilca, Florin Tudor, Zacharias, Martin, Springer, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535769/ https://www.ncbi.nlm.nih.gov/pubmed/26270965 http://dx.doi.org/10.1371/journal.pone.0135421

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