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Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia

BACKGROUND: A subset of the population receiving opioids for the treatment of acute and chronic clinical pain develops a paradoxical increase in pain sensitivity known as opioid-induced hyperalgesia. Given that opioid analgesics are one of few treatments available against clinical pain, it is critic...

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Detalles Bibliográficos
Autores principales: Oladosu, Folabomi A., Conrad, Matthew S., O’Buckley, Sandra C., Rashid, Naim U., Slade, Gary D., Nackley, Andrea G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535978/
https://www.ncbi.nlm.nih.gov/pubmed/26270813
http://dx.doi.org/10.1371/journal.pone.0135711