The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells — A data description

A large number of breast cancers are characterized by amplification and overexpression of the chromosome segment surrounding the HER2 (ERBB2) oncogene. As the HER2 amplicon at 17q12 contains multiple genes, we have systematically explored the role of the HER2 co-amplified genes in breast cancer cell...

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Autores principales: Hongisto, Vesa, Aure, Miriam Ragle, Mäkelä, Rami, Sahlberg, Kristine Kleivi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Data in Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536024/
https://www.ncbi.nlm.nih.gov/pubmed/26484103
http://dx.doi.org/10.1016/j.gdata.2014.06.025
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author Hongisto, Vesa
Aure, Miriam Ragle
Mäkelä, Rami
Sahlberg, Kristine Kleivi
author_facet Hongisto, Vesa
Aure, Miriam Ragle
Mäkelä, Rami
Sahlberg, Kristine Kleivi
author_sort Hongisto, Vesa
collection PubMed
description A large number of breast cancers are characterized by amplification and overexpression of the chromosome segment surrounding the HER2 (ERBB2) oncogene. As the HER2 amplicon at 17q12 contains multiple genes, we have systematically explored the role of the HER2 co-amplified genes in breast cancer cell growth and their relation to trastuzumab resistance. We integrated array comparative genomic hybridization (aCGH) data of the HER2 amplicon from 71 HER2 positive breast tumors and 10 cell lines with systematic functional RNA interference analysis of 23 core amplicon genes with several phenotypic endpoints in a panel of trastuzumab responding and non-responding HER2 positive breast cancer cells. In this Data in Brief we give a detailed description of the experimental procedures and the data analysis methods used in the study (1).
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spelling pubmed-45360242015-10-19 The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells — A data description Hongisto, Vesa Aure, Miriam Ragle Mäkelä, Rami Sahlberg, Kristine Kleivi Genom Data Data in Brief A large number of breast cancers are characterized by amplification and overexpression of the chromosome segment surrounding the HER2 (ERBB2) oncogene. As the HER2 amplicon at 17q12 contains multiple genes, we have systematically explored the role of the HER2 co-amplified genes in breast cancer cell growth and their relation to trastuzumab resistance. We integrated array comparative genomic hybridization (aCGH) data of the HER2 amplicon from 71 HER2 positive breast tumors and 10 cell lines with systematic functional RNA interference analysis of 23 core amplicon genes with several phenotypic endpoints in a panel of trastuzumab responding and non-responding HER2 positive breast cancer cells. In this Data in Brief we give a detailed description of the experimental procedures and the data analysis methods used in the study (1). Elsevier 2014-07-22 /pmc/articles/PMC4536024/ /pubmed/26484103 http://dx.doi.org/10.1016/j.gdata.2014.06.025 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Data in Brief
Hongisto, Vesa
Aure, Miriam Ragle
Mäkelä, Rami
Sahlberg, Kristine Kleivi
The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells — A data description
title The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells — A data description
title_full The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells — A data description
title_fullStr The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells — A data description
title_full_unstemmed The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells — A data description
title_short The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells — A data description
title_sort her2 amplicon includes several genes required for the growth and survival of her2 positive breast cancer cells — a data description
topic Data in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536024/
https://www.ncbi.nlm.nih.gov/pubmed/26484103
http://dx.doi.org/10.1016/j.gdata.2014.06.025
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