A Targeted Oligonucleotide Enhancer of SMN2 Exon 7 Splicing Forms Competing Quadruplex and Protein Complexes in Functional Conditions

The use of oligonucleotides to activate the splicing of selected exons is limited by a poor understanding of the mechanisms affected. A targeted bifunctional oligonucleotide enhancer of splicing (TOES) anneals to SMN2 exon 7 and carries an exonic splicing enhancer (ESE) sequence. We show that it sti...

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Detalles Bibliográficos
Autores principales: Smith, Lindsay D., Dickinson, Rachel L., Lucas, Christian M., Cousins, Alex, Malygin, Alexey A., Weldon, Carika, Perrett, Andrew J., Bottrill, Andrew R., Searle, Mark S., Burley, Glenn A., Eperon, Ian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536295/
https://www.ncbi.nlm.nih.gov/pubmed/25263560
http://dx.doi.org/10.1016/j.celrep.2014.08.051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536295/
https://www.ncbi.nlm.nih.gov/pubmed/25263560
http://dx.doi.org/10.1016/j.celrep.2014.08.051

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