DNA break-induced sumoylation is enabled by collaboration between a SUMO ligase and the ssDNA-binding complex RPA

Upon genome damage, large-scale protein sumoylation occurs from yeast to humans to promote DNA repair. Currently, the underlying mechanism is largely unknown. Here we show that, upon DNA break induction, the budding yeast SUMO ligase Siz2 collaborates with the ssDNA-binding complex RPA (replication...

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Detalles Bibliográficos
Autores principales: Chung, Inn, Zhao, Xiaolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536307/
https://www.ncbi.nlm.nih.gov/pubmed/26253534
http://dx.doi.org/10.1101/gad.265058.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536307/
https://www.ncbi.nlm.nih.gov/pubmed/26253534
http://dx.doi.org/10.1101/gad.265058.115

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