AUF1 promotes let-7b loading on Argonaute 2

Eukaryotic gene expression is tightly regulated post-transcriptionally by RNA-binding proteins (RBPs) and microRNAs. The RBP AU-rich-binding factor 1 (AUF1) isoform p37 was found to have high affinity for the microRNA let-7b in vitro (K(d) = ∼6 nM) in cells. Ribonucleoprotein immunoprecipitation, in...

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Detalles Bibliográficos
Autores principales: Yoon, Je-Hyun, Jo, Myung Hyun, White, Elizabeth J.F., De, Supriyo, Hafner, Markus, Zucconi, Beth E., Abdelmohsen, Kotb, Martindale, Jennifer L., Yang, Xiaoling, Wood, William H., Shin, Yu Mi, Song, Ji-Joon, Tuschl, Thomas, Becker, Kevin G., Wilson, Gerald M., Hohng, Sungchul, Gorospe, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536308/
https://www.ncbi.nlm.nih.gov/pubmed/26253535
http://dx.doi.org/10.1101/gad.263749.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536308/
https://www.ncbi.nlm.nih.gov/pubmed/26253535
http://dx.doi.org/10.1101/gad.263749.115

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