MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells

In many mouse models of skin cancer, only a few tumors typically form even though many cells competent for tumorigenesis receive the same oncogenic stimuli. These observations suggest an active selection process for tumor-initiating cells. Here, we use quantitative mRNA- and miR-Seq to determine the...

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Detalles Bibliográficos
Autores principales: Riemondy, Kent, Wang, Xiao-jing, Torchia, Enrique C, Roop, Dennis R, Yi, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536367/
https://www.ncbi.nlm.nih.gov/pubmed/26203562
http://dx.doi.org/10.7554/eLife.07004