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Defects in Germinal Center Selection in SLE

Germinal centers (GCs) are the primary site at which clonal expansion and affinity maturation of B cells occur. B cells encounter antigen and receive T cell help in the GC light zone (LZ) and then migrate to the dark zone where they proliferate and undergo somatic mutation before cycling back to the...

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Detalles Bibliográficos
Autores principales: Woods, Megan, Zou, Yong-Rui, Davidson, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536402/
https://www.ncbi.nlm.nih.gov/pubmed/26322049
http://dx.doi.org/10.3389/fimmu.2015.00425