UPRT, a suicide-gene therapy candidate in higher eukaryotes, is required for Drosophila larval growth and normal adult lifespan

Uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage pathway enzyme that catalyzes the conversion of uracil to uridine monophosphate (UMP). The enzyme is highly conserved from prokaryotes to humans and yet phylogenetic evidence suggests that UPRT homologues from higher-eukaryotes, includi...

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Detalles Bibliográficos
Autores principales: Ghosh, Arpan C., Shimell, MaryJane, Leof, Emma R., Haley, Macy J., O’Connor, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536494/
https://www.ncbi.nlm.nih.gov/pubmed/26271729
http://dx.doi.org/10.1038/srep13176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536494/
https://www.ncbi.nlm.nih.gov/pubmed/26271729
http://dx.doi.org/10.1038/srep13176

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