IL-33 released by alum is responsible for early cytokine production and has adjuvant properties

Human vaccines have used aluminium-based adjuvants (alum) for >80 years despite incomplete understanding of how alum enhances the immune response. Alum can induce the release of endogenous danger signals via cellular necrosis which elicits inflammation-associated cytokines resulting in humoral im...

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Detalles Bibliográficos
Autores principales: Rose II, William A., Okragly, Angela J., Patel, Chetan N., Benschop, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536651/
https://www.ncbi.nlm.nih.gov/pubmed/26272855
http://dx.doi.org/10.1038/srep13146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536651/
https://www.ncbi.nlm.nih.gov/pubmed/26272855
http://dx.doi.org/10.1038/srep13146

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