Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study
BACKGROUND: Existing epidemiological studies of the association between oxidative stress and erectile dysfunction (ED) are sparse and inconclusive, which is likely due to cross-sectional design and small sample size. Therefore, we investigated the association between biomarkers of oxidative stress a...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536733/ https://www.ncbi.nlm.nih.gov/pubmed/26272213 http://dx.doi.org/10.1186/s12894-015-0083-9 |
_version_ | 1782385788785262592 |
---|---|
author | Yang, Shuman Giovannucci, Edward Bracken, Bruce Ho, Shuk-Mei Wu, Tianying |
author_facet | Yang, Shuman Giovannucci, Edward Bracken, Bruce Ho, Shuk-Mei Wu, Tianying |
author_sort | Yang, Shuman |
collection | PubMed |
description | BACKGROUND: Existing epidemiological studies of the association between oxidative stress and erectile dysfunction (ED) are sparse and inconclusive, which is likely due to cross-sectional design and small sample size. Therefore, we investigated the association between biomarkers of oxidative stress and ED in prospective setting among a relatively large sample size of men. METHODS: We conducted the prospective study among 917 men ages between 47 and 80 years at the time of blood draw, which is a part of nested prospective case–control study of prostate cancer in the Health Professionals Follow-up Study. Plasma fluorescent oxidation products (FlOPs), a global biomarker for oxidative stress, were measured at three excitation/emission wavelengths (360/420 nm named as FlOP_360; 320/420 nm named as FlOP_320 and 400/475 nm named as FlOP_400). RESULTS: Approximately 35 % of men developed ED during follow-up. We did not find an independent association between FlOP_360, FlOP_320, FlOP_400 and risk of ED in the multivariable adjusted model (Tertile 3 vs. tertile 1: odds ratio [OR] = 0.90, 95 % confidence interval [CI] = 0.61-1.34, P(trend) = 0.54 for FlOP_360; OR = 0.73, 95 % CI = 0.49-1.07, P(trend) = 0.27 for FlOP_320; and OR = 0.98, 95 % CI = 0.66-1.45, P(trend) = 0.72 for FlOP_400). Further analysis of the association between FlOPs and ED in the fasting samples or controls only (free of prostate cancer incidence) did not change the results appreciably. CONCLUSIONS: Plasma FlOPs were not associated with the risk of ED, suggesting oxidative stress may not be an independent risk factor for ED. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12894-015-0083-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4536733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45367332015-08-15 Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study Yang, Shuman Giovannucci, Edward Bracken, Bruce Ho, Shuk-Mei Wu, Tianying BMC Urol Research Article BACKGROUND: Existing epidemiological studies of the association between oxidative stress and erectile dysfunction (ED) are sparse and inconclusive, which is likely due to cross-sectional design and small sample size. Therefore, we investigated the association between biomarkers of oxidative stress and ED in prospective setting among a relatively large sample size of men. METHODS: We conducted the prospective study among 917 men ages between 47 and 80 years at the time of blood draw, which is a part of nested prospective case–control study of prostate cancer in the Health Professionals Follow-up Study. Plasma fluorescent oxidation products (FlOPs), a global biomarker for oxidative stress, were measured at three excitation/emission wavelengths (360/420 nm named as FlOP_360; 320/420 nm named as FlOP_320 and 400/475 nm named as FlOP_400). RESULTS: Approximately 35 % of men developed ED during follow-up. We did not find an independent association between FlOP_360, FlOP_320, FlOP_400 and risk of ED in the multivariable adjusted model (Tertile 3 vs. tertile 1: odds ratio [OR] = 0.90, 95 % confidence interval [CI] = 0.61-1.34, P(trend) = 0.54 for FlOP_360; OR = 0.73, 95 % CI = 0.49-1.07, P(trend) = 0.27 for FlOP_320; and OR = 0.98, 95 % CI = 0.66-1.45, P(trend) = 0.72 for FlOP_400). Further analysis of the association between FlOPs and ED in the fasting samples or controls only (free of prostate cancer incidence) did not change the results appreciably. CONCLUSIONS: Plasma FlOPs were not associated with the risk of ED, suggesting oxidative stress may not be an independent risk factor for ED. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12894-015-0083-9) contains supplementary material, which is available to authorized users. BioMed Central 2015-08-14 /pmc/articles/PMC4536733/ /pubmed/26272213 http://dx.doi.org/10.1186/s12894-015-0083-9 Text en © Yang et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Yang, Shuman Giovannucci, Edward Bracken, Bruce Ho, Shuk-Mei Wu, Tianying Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study |
title | Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study |
title_full | Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study |
title_fullStr | Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study |
title_full_unstemmed | Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study |
title_short | Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study |
title_sort | association between plasma fluorescent oxidation products and erectile dysfunction: a prospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536733/ https://www.ncbi.nlm.nih.gov/pubmed/26272213 http://dx.doi.org/10.1186/s12894-015-0083-9 |
work_keys_str_mv | AT yangshuman associationbetweenplasmafluorescentoxidationproductsanderectiledysfunctionaprospectivestudy AT giovannucciedward associationbetweenplasmafluorescentoxidationproductsanderectiledysfunctionaprospectivestudy AT brackenbruce associationbetweenplasmafluorescentoxidationproductsanderectiledysfunctionaprospectivestudy AT hoshukmei associationbetweenplasmafluorescentoxidationproductsanderectiledysfunctionaprospectivestudy AT wutianying associationbetweenplasmafluorescentoxidationproductsanderectiledysfunctionaprospectivestudy |