Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study

BACKGROUND: Existing epidemiological studies of the association between oxidative stress and erectile dysfunction (ED) are sparse and inconclusive, which is likely due to cross-sectional design and small sample size. Therefore, we investigated the association between biomarkers of oxidative stress a...

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Autores principales: Yang, Shuman, Giovannucci, Edward, Bracken, Bruce, Ho, Shuk-Mei, Wu, Tianying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536733/
https://www.ncbi.nlm.nih.gov/pubmed/26272213
http://dx.doi.org/10.1186/s12894-015-0083-9
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author Yang, Shuman
Giovannucci, Edward
Bracken, Bruce
Ho, Shuk-Mei
Wu, Tianying
author_facet Yang, Shuman
Giovannucci, Edward
Bracken, Bruce
Ho, Shuk-Mei
Wu, Tianying
author_sort Yang, Shuman
collection PubMed
description BACKGROUND: Existing epidemiological studies of the association between oxidative stress and erectile dysfunction (ED) are sparse and inconclusive, which is likely due to cross-sectional design and small sample size. Therefore, we investigated the association between biomarkers of oxidative stress and ED in prospective setting among a relatively large sample size of men. METHODS: We conducted the prospective study among 917 men ages between 47 and 80 years at the time of blood draw, which is a part of nested prospective case–control study of prostate cancer in the Health Professionals Follow-up Study. Plasma fluorescent oxidation products (FlOPs), a global biomarker for oxidative stress, were measured at three excitation/emission wavelengths (360/420 nm named as FlOP_360; 320/420 nm named as FlOP_320 and 400/475 nm named as FlOP_400). RESULTS: Approximately 35 % of men developed ED during follow-up. We did not find an independent association between FlOP_360, FlOP_320, FlOP_400 and risk of ED in the multivariable adjusted model (Tertile 3 vs. tertile 1: odds ratio [OR] = 0.90, 95 % confidence interval [CI] = 0.61-1.34, P(trend) = 0.54 for FlOP_360; OR = 0.73, 95 % CI = 0.49-1.07, P(trend) = 0.27 for FlOP_320; and OR = 0.98, 95 % CI = 0.66-1.45, P(trend) = 0.72 for FlOP_400). Further analysis of the association between FlOPs and ED in the fasting samples or controls only (free of prostate cancer incidence) did not change the results appreciably. CONCLUSIONS: Plasma FlOPs were not associated with the risk of ED, suggesting oxidative stress may not be an independent risk factor for ED. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12894-015-0083-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-45367332015-08-15 Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study Yang, Shuman Giovannucci, Edward Bracken, Bruce Ho, Shuk-Mei Wu, Tianying BMC Urol Research Article BACKGROUND: Existing epidemiological studies of the association between oxidative stress and erectile dysfunction (ED) are sparse and inconclusive, which is likely due to cross-sectional design and small sample size. Therefore, we investigated the association between biomarkers of oxidative stress and ED in prospective setting among a relatively large sample size of men. METHODS: We conducted the prospective study among 917 men ages between 47 and 80 years at the time of blood draw, which is a part of nested prospective case–control study of prostate cancer in the Health Professionals Follow-up Study. Plasma fluorescent oxidation products (FlOPs), a global biomarker for oxidative stress, were measured at three excitation/emission wavelengths (360/420 nm named as FlOP_360; 320/420 nm named as FlOP_320 and 400/475 nm named as FlOP_400). RESULTS: Approximately 35 % of men developed ED during follow-up. We did not find an independent association between FlOP_360, FlOP_320, FlOP_400 and risk of ED in the multivariable adjusted model (Tertile 3 vs. tertile 1: odds ratio [OR] = 0.90, 95 % confidence interval [CI] = 0.61-1.34, P(trend) = 0.54 for FlOP_360; OR = 0.73, 95 % CI = 0.49-1.07, P(trend) = 0.27 for FlOP_320; and OR = 0.98, 95 % CI = 0.66-1.45, P(trend) = 0.72 for FlOP_400). Further analysis of the association between FlOPs and ED in the fasting samples or controls only (free of prostate cancer incidence) did not change the results appreciably. CONCLUSIONS: Plasma FlOPs were not associated with the risk of ED, suggesting oxidative stress may not be an independent risk factor for ED. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12894-015-0083-9) contains supplementary material, which is available to authorized users. BioMed Central 2015-08-14 /pmc/articles/PMC4536733/ /pubmed/26272213 http://dx.doi.org/10.1186/s12894-015-0083-9 Text en © Yang et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yang, Shuman
Giovannucci, Edward
Bracken, Bruce
Ho, Shuk-Mei
Wu, Tianying
Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study
title Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study
title_full Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study
title_fullStr Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study
title_full_unstemmed Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study
title_short Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study
title_sort association between plasma fluorescent oxidation products and erectile dysfunction: a prospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536733/
https://www.ncbi.nlm.nih.gov/pubmed/26272213
http://dx.doi.org/10.1186/s12894-015-0083-9
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