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Getting the genome in shape: the formation of loops, domains and compartments
The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformatio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536798/ https://www.ncbi.nlm.nih.gov/pubmed/26257189 http://dx.doi.org/10.1186/s13059-015-0730-1 |
| _version_ | 1782385801726787584 |
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| author | Bouwman, Britta AM de Laat, Wouter |
| author_facet | Bouwman, Britta AM de Laat, Wouter |
| author_sort | Bouwman, Britta AM |
| collection | PubMed |
| description | The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations. |
| format | Online Article Text |
| id | pubmed-4536798 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-45367982015-08-15 Getting the genome in shape: the formation of loops, domains and compartments Bouwman, Britta AM de Laat, Wouter Genome Biol Review The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations. BioMed Central 2015-08-10 2015 /pmc/articles/PMC4536798/ /pubmed/26257189 http://dx.doi.org/10.1186/s13059-015-0730-1 Text en © Bouwman and de Laat. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Review Bouwman, Britta AM de Laat, Wouter Getting the genome in shape: the formation of loops, domains and compartments |
| title | Getting the genome in shape: the formation of loops, domains and compartments |
| title_full | Getting the genome in shape: the formation of loops, domains and compartments |
| title_fullStr | Getting the genome in shape: the formation of loops, domains and compartments |
| title_full_unstemmed | Getting the genome in shape: the formation of loops, domains and compartments |
| title_short | Getting the genome in shape: the formation of loops, domains and compartments |
| title_sort | getting the genome in shape: the formation of loops, domains and compartments |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536798/ https://www.ncbi.nlm.nih.gov/pubmed/26257189 http://dx.doi.org/10.1186/s13059-015-0730-1 |
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