Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma

Human multiple myeloma (MM) is characterized by accumulation of malignant terminally differentiated plasma cells (PCs) in the bone marrow (BM), raising the question when during maturation neoplastic transformation begins. Immunoglobulin IGHV genes carry imprints of clonal tumor history, delineating...

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Detalles Bibliográficos
Autores principales: Cowan, Graeme, Weston-Bell, Nicola J., Bryant, Dean, Seckinger, Anja, Hose, Dirk, Zojer, Niklas, Sahota, Surinder S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537010/
https://www.ncbi.nlm.nih.gov/pubmed/25929340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537010/
https://www.ncbi.nlm.nih.gov/pubmed/25929340

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