A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

Herein, we evaluated the anti-cancer effect and molecular mechanisms of a novel betulinic acid (BA) derivative, SYK023, by using two mouse models of lung cancer driven by Kras(G12D) or EGFR(L858R). We found that SYK023 inhibits lung tumor proliferation, without side effects in vivo or cytotoxicity i...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsu, Tsung-I, Chen, Ying-Jung, Hung, Chia-Yang, Wang, Yi-Chang, Lin, Sin-Jin, Su, Wu-Chou, Lai, Ming-Derg, Kim, Sang-Yong, Wang, Qiang, Qian, Keduo, Goto, Masuo, Zhao, Yu, Kashiwada, Yoshiki, Lee, Kuo-Hsiung, Chang, Wen-Chang, Hung, Jan-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537041/
https://www.ncbi.nlm.nih.gov/pubmed/25909174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537041/
https://www.ncbi.nlm.nih.gov/pubmed/25909174

Ejemplares similares