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A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy
Herein, we evaluated the anti-cancer effect and molecular mechanisms of a novel betulinic acid (BA) derivative, SYK023, by using two mouse models of lung cancer driven by Kras(G12D) or EGFR(L858R). We found that SYK023 inhibits lung tumor proliferation, without side effects in vivo or cytotoxicity i...
Autores principales: | Hsu, Tsung-I, Chen, Ying-Jung, Hung, Chia-Yang, Wang, Yi-Chang, Lin, Sin-Jin, Su, Wu-Chou, Lai, Ming-Derg, Kim, Sang-Yong, Wang, Qiang, Qian, Keduo, Goto, Masuo, Zhao, Yu, Kashiwada, Yoshiki, Lee, Kuo-Hsiung, Chang, Wen-Chang, Hung, Jan-Jong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537041/ https://www.ncbi.nlm.nih.gov/pubmed/25909174 |
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