The relationship between target-class and the physicochemical properties of antibacterial drugs

The discovery of novel mechanism of action (MOA) antibacterials has been associated with the concept that antibacterial drugs occupy a differentiated region of physicochemical space compared to human-targeted drugs. With, in broad terms, antibacterials having higher molecular weight, lower log P and...

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Detalles Bibliográficos
Autores principales: Mugumbate, Grace, Overington, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537081/
https://www.ncbi.nlm.nih.gov/pubmed/25975639
http://dx.doi.org/10.1016/j.bmc.2015.04.063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537081/
https://www.ncbi.nlm.nih.gov/pubmed/25975639
http://dx.doi.org/10.1016/j.bmc.2015.04.063

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