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The relationship between target-class and the physicochemical properties of antibacterial drugs
The discovery of novel mechanism of action (MOA) antibacterials has been associated with the concept that antibacterial drugs occupy a differentiated region of physicochemical space compared to human-targeted drugs. With, in broad terms, antibacterials having higher molecular weight, lower log P and...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537081/ https://www.ncbi.nlm.nih.gov/pubmed/25975639 http://dx.doi.org/10.1016/j.bmc.2015.04.063 |