Cargando…

Ribavirin Contributes to Hepatitis C Virus Suppression by Augmenting pDC Activation and Type 1 IFN Production

Ribavirin is used as a component of combination therapies for the treatment of chronic hepatitis C virus (HCV) infection together with pegylated interferon and/or direct-acting antiviral drugs. Its mechanism of action, however, is not clear. Direct antiviral activity and immunomodulatory functions h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yang, McGivern, David R, Cheng, Liang, Li, Guangming, Lemon, Stanley M, Niu, Junqi, Su, Lishan, Reszka-Blanco, Natalia J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537094/ https://www.ncbi.nlm.nih.gov/pubmed/26274905 http://dx.doi.org/10.1371/journal.pone.0135232

Ejemplares similares

Implications of post-translational modifications of IRF7 on pDC IFN-alpha response
por: Griesbeck, M, et al.
Publicado: (2012)

pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation
por: Duraes, Fernanda V., et al.
Publicado: (2016)

HIV-1 infection depletes human CD34(+)CD38(-) hematopoietic progenitor cells via pDC-dependent mechanisms
por: Li, Guangming, et al.
Publicado: (2017)

Hassall’s corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus
por: Wang, Jianwei, et al.
Publicado: (2018)

IFN-α Regulates Blimp-1 Expression via miR-23a and miR-125b in Both Monocytes-Derived DC and pDC
por: Parlato, Stefania, et al.
Publicado: (2013)

What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity
por: Musumeci, Andrea, et al.
Publicado: (2019)

TLR9- and CD40-Targeting Vaccination Promotes Human B Cell Maturation and IgG Induction via pDC-Dependent Mechanisms in Humanized Mice
por: Cheng, Liang, et al.
Publicado: (2021)

Chronic hepatitis C infection–induced liver fibrogenesis is associated with M2 macrophage activation
por: Bility, Moses T., et al.
Publicado: (2016)

Heterogeneous Escape from X Chromosome Inactivation Results in Sex Differences in Type I IFN Responses at the Single Human pDC Level
por: Hagen, Sven Hendrik, et al.
Publicado: (2020)

OA011-05. TLR-mediated pDC responses to HIV-1 ligands
por: Chang, J, et al.
Publicado: (2009)

Primary Human mDC1, mDC2, and pDC Dendritic Cells Are Differentially Infected and Activated by Respiratory Syncytial Virus
por: Johnson, Teresa R., et al.
Publicado: (2011)

CXCR3 chemokine receptor contributes to specific CD8(+) T cell activation by pDC during infection with intracellular pathogens
por: Pontes Ferreira, Camila, et al.
Publicado: (2020)

Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development
por: Mastio, Jérôme, et al.
Publicado: (2018)

Monocytes Exposed to Immune Complexes Reduce pDC Type 1 Interferon Response to Vidutolimod
por: Sabree, Shakoora A., et al.
Publicado: (2021)

Correction: CXCR3 chemokine receptor contributes to specific CD8(+) T cell activation by pDC during infection with intracellular pathogens
por: Ferreira, Camila Pontes, et al.
Publicado: (2021)

O19 - Changes in the balance between myeloid (mDC) and plasmacytoid (pDC) cell numbers in peripheral blood during childhood
por: Maggina, Paraskevi, et al.
Publicado: (2014)

Respiratory Syncytial Virus Induced Type I IFN Production by pDC Is Regulated by RSV-Infected Airway Epithelial Cells, RSV-Exposed Monocytes and Virus Specific Antibodies
por: Schijf, Marcel A., et al.
Publicado: (2013)

Effect of in vivo Hydroxychloroquine and ex vivo Anti-BDCA2 mAb Treatment on pDC IFNα Production From Patients Affected With Cutaneous Lupus Erythematosus
por: Gardet, Agnes, et al.
Publicado: (2019)

The appeal of the PDC program
por: Wasow, Thomas
Publicado: (2013)

Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state
por: Swiecki, Melissa, et al.
Publicado: (2016)

Hepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma Protein
por: Munakata, Tsubasa, et al.
Publicado: (2007)

Class A Scavenger Receptor 1 (MSR1) Restricts Hepatitis C Virus Replication by Mediating Toll-like Receptor 3 Recognition of Viral RNAs Produced in Neighboring Cells
por: Dansako, Hiromichi, et al.
Publicado: (2013)

Test of IL28B Polymorphisms in Chronic Hepatitis C Patients Treated with PegIFN and Ribavirin Depends on HCV Genotypes: Results from a Meta-Analysis
por: Jia, Zhifang, et al.
Publicado: (2012)

The Dox-pDC - A murine conditionally immortalized plasmacytoid dendritic cell line with native immune profile
por: Thieme, Sebastian, et al.
Publicado: (2018)

NK-pDC cross-talk leads to the generation of mTRAIL+IFN-α+cytotoxic pDCs following HIV-1 infection of pDCs. Consequences on the control of viral replication
por: Saïdi, Héla, et al.
Publicado: (2010)

Follow Up After PEG Tube Insertion
por: McGivern, Margaret
Publicado: (2007)

Bcl11a Controls Flt3 Expression in Early Hematopoietic Progenitors and Is Required for pDC Development In Vivo
por: Wu, Xiaodi, et al.
Publicado: (2013)

The PDC framework applied to prosody and disfluency
por: Ferreira, Fernanda
Publicado: (2013)

Ziconotide: a review of its pharmacology and use in the treatment of pain
por: McGivern, Joseph G
Publicado: (2007)

Lupus IgA1 autoantibodies synergize with IgG to enhance pDC responses to RNA-containing immune complexes
por: Waterman, Hayley R., et al.
Publicado: (2023)

Slc15a4, a Gene Required for pDC Sensing of TLR Ligands, Is Required to Control Persistent Viral Infection
por: Blasius, Amanda L., et al.
Publicado: (2012)

Student polling software: where cognitive psychology meets educational practice?
por: McGivern, Paul, et al.
Publicado: (2015)

The impact of COVID-19 on UK university students: Understanding the interconnection of issues experienced during lockdown
por: McGivern, Paul, et al.
Publicado: (2022)

Antitumor effects of ribavirin in combination with TMZ and IFN-β in malignant glioma cells
por: Ochiai, Yushi, et al.
Publicado: (2020)

miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation
por: Masaki, Takahiro, et al.
Publicado: (2015)

Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R
por: Mitchell, Jonathan K., et al.
Publicado: (2017)

pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG
por: Wu, Jing, et al.
Publicado: (2019)

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains
por: Benzine, Tiffany, et al.
Publicado: (2017)

‘Pastoral practices’ for quality improvement in a Kenyan clinical network
por: McGivern, Gerry, et al.
Publicado: (2017)

Examining clinical leadership in Kenyan public hospitals through the distributed leadership lens
por: Nzinga, Jacinta, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4dl1o3bqsdjqak7g7eo5jljd7r