Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation

Targeted mutations in mouse disrupt local chromatin structure and may lead to unanticipated local effects. We evaluated targeted gene promoter silencing in a group of six mutants carrying the tm1a Knockout Mouse Project allele containing both a LacZ reporter gene driven by the native promoter and a...

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Detalles Bibliográficos
Autores principales: Kirov, Julia V., Adkisson, Michael, Nava, A. J., Cipollone, Andreana, Willis, Brandon, Engelhard, Eric K., Lloyd, K. C. Kent, de Jong, Pieter, West, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537176/
https://www.ncbi.nlm.nih.gov/pubmed/26275310
http://dx.doi.org/10.1371/journal.pone.0134155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537176/
https://www.ncbi.nlm.nih.gov/pubmed/26275310
http://dx.doi.org/10.1371/journal.pone.0134155

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