Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses
RATIONALE: Dopamine stabilizers have stimulatory actions under low dopamine tone and inhibitory actions under high dopamine tone without eliciting catalepsy. These compounds are dopamine D(2) receptor (D(2)R) antagonists or weak partial agonists and may have pro-mnemonic and neuroprotective effects....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537502/ https://www.ncbi.nlm.nih.gov/pubmed/26159455 http://dx.doi.org/10.1007/s00213-015-3997-8 |