Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses

RATIONALE: Dopamine stabilizers have stimulatory actions under low dopamine tone and inhibitory actions under high dopamine tone without eliciting catalepsy. These compounds are dopamine D(2) receptor (D(2)R) antagonists or weak partial agonists and may have pro-mnemonic and neuroprotective effects....

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Detalles Bibliográficos
Autores principales: Sahlholm, Kristoffer, Sijbesma, Jurgen W. A., Maas, Bram, Kwizera, Chantal, Marcellino, Daniel, Ramakrishnan, Nisha K., Dierckx, Rudi A. J. O., Elsinga, Philip H., van Waarde, Aren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537502/
https://www.ncbi.nlm.nih.gov/pubmed/26159455
http://dx.doi.org/10.1007/s00213-015-3997-8

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