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Models of buffering of dosage imbalances in protein complexes
BACKGROUND: Stoichiometric imbalances in macromolecular complexes can lead to altered function. Such imbalances stem from under- or over-expression of a subunit of a complex consequent to a deletion, duplication or regulatory mutation of an allele encoding the relevant protein. In some cases, the ph...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537584/ https://www.ncbi.nlm.nih.gov/pubmed/26275824 http://dx.doi.org/10.1186/s13062-015-0063-8 |