Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability

The Notch signalling pathway is fundamental to cell differentiation in developing and self-renewing tissues. Notch is activated upon ligand-induced conformational change of the Notch negative regulatory region (NRR), unmasking a key proteolytic site (S2) and facilitating downstream events. The favou...

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Detalles Bibliográficos
Autores principales: Stephenson, Natalie L., Avis, Johanna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537882/
https://www.ncbi.nlm.nih.gov/pubmed/26288744
http://dx.doi.org/10.1016/j.fob.2015.07.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537882/
https://www.ncbi.nlm.nih.gov/pubmed/26288744
http://dx.doi.org/10.1016/j.fob.2015.07.006

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