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Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability
The Notch signalling pathway is fundamental to cell differentiation in developing and self-renewing tissues. Notch is activated upon ligand-induced conformational change of the Notch negative regulatory region (NRR), unmasking a key proteolytic site (S2) and facilitating downstream events. The favou...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537882/ https://www.ncbi.nlm.nih.gov/pubmed/26288744 http://dx.doi.org/10.1016/j.fob.2015.07.006 |