Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

One reported mechanism for morphine activation of dopamine (DA) neurons of the ventral tegmental area (VTA) is the disinhibition model of VTA-DA neurons. Morphine inhibits GABA inhibitory neurons, which shifts the balance between inhibitory and excitatory input to VTA-DA neurons in favor of excitati...

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Detalles Bibliográficos
Autores principales: Chen, Ming, Zhao, Yanfang, Yang, Hualan, Luan, Wenjie, Song, Jiaojiao, Cui, Dongyang, Dong, Yi, Lai, Bin, Ma, Lan, Zheng, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538365/
https://www.ncbi.nlm.nih.gov/pubmed/26208338
http://dx.doi.org/10.7554/eLife.09275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538365/
https://www.ncbi.nlm.nih.gov/pubmed/26208338
http://dx.doi.org/10.7554/eLife.09275

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