TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer

To determine early somatic changes in high-grade serous ovarian cancer (HGSOC), we performed whole genome sequencing on a rare collection of 16 low stage HGSOCs. The majority showed extensive structural alterations (one had an ultramutated profile), exhibited high levels of p53 immunoreactivity, and...

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Detalles Bibliográficos
Autores principales: Chien, Jeremy, Sicotte, Hugues, Fan, Jian-Bing, Humphray, Sean, Cunningham, Julie M., Kalli, Kimberly R., Oberg, Ann L., Hart, Steven N., Li, Ying, Davila, Jaime I., Baheti, Saurabh, Wang, Chen, Dietmann, Sabine, Atkinson, Elizabeth J., Asmann, Yan W., Bell, Debra A., Ota, Takayo, Tarabishy, Yaman, Kuang, Rui, Bibikova, Marina, Cheetham, R. Keira, Grocock, Russell J., Swisher, Elizabeth M., Peden, John, Bentley, David, Kocher, Jean-Pierre A., Kaufmann, Scott H., Hartmann, Lynn C., Shridhar, Viji, Goode, Ellen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538798/
https://www.ncbi.nlm.nih.gov/pubmed/25916844
http://dx.doi.org/10.1093/nar/gkv111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538798/
https://www.ncbi.nlm.nih.gov/pubmed/25916844
http://dx.doi.org/10.1093/nar/gkv111

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